Technical Articles
Articles/Authors Publications
For recently published articles or presentations, please click on the hyperlinks below:
ANTIAGING AND WOUND HEALING PROPERTIES OF POUTERIA LUCUMA SEED EXTRACT
Leonel E. Rojo, Caren Villano, Vladimir Shulaev, Nava Dayan, Mary Ann Lila, Ilya Raskin October 2010
- Rutgers University, 59 Dudley Rd., New Brunswick, NJ 08901, USA
- Virginia Bioinformatics Institute
- North Carolina State University, 600 Laureate Way, Kannapolis, NC 28081
- Lipo Chemicals Inc, 207, 19TH Avenue, Paterson NJ, 07504
Presented at the NYSCC Technology Conference October 20th 2010
“Wound healing and skin aging share common biochemical cascades, such as the accumulation of free radicals, the formation of extra cellular gaps, accelerated cell senescence, inflammation, extracellular matrix remodeling and re-epithelialization.”
Skin moisturization by hydrogenated polyisobutene---Quantitative and visual evaluation
Dayan, N, Ph.D., Sivalenka, R., Ph.D., and John Chase February 2009
This article reports that when Hydrogenated polyisobutene (HP) is used in topically applied cosmetic/personal care formulations as an emollient it leaves a pleasing skin feel when applied, and rubbed in after application A quantiative and visual evaluation
In Vitro Absorption Guidelines for Cosmetic Ingredients
Dayan N. February 2008
Data on Skin absorption of cosmetic ingredients is essential to assure safe use of products. Such studies are validated and regulated by international regulatory bodies such as OECD, CTFA (now Personal Care Products Council) and WHO. This article outlines the design, methodology and result documentation for in vitro skin absorption studies for topically applied compounds.
Effect on In Vitro Tryptophan Levels in Human Skin During Treatment with Hydrxycinnamic Acid, Magnesium Ascorbyl Phospate and Hydroquinone.
Dayan, N and Miller, T September 2007
Hydroxycinnamic Acid (HCA) is an anti-oxidant with a radical scavenging activity. It has also been shown to inhibit the rate-limiting enzyme tyrosinase in the biochemical production of melanin. An eight-week take home pilot study was conducted in Asian women to study the reduction in epidermal tryptophan levels. HCA showed superiority over hydroquinone and magnesium ascorbyl phosphor in reduction of tryptophan levels.
Epidermal Targeting: Controlled Topical Delivery of Salicylic Acid
Nava Dayan, Ph. D. and K. Basak June 2007
This article presents a novel technology to deliver Salicylic acid to epidermis. The polymeric porous particle delivery system described herein minimizes skin irritation, aids in overcoming many drawbacks with application of free salycylic acid. Its effectiveness is demonstrated in a relative cumulative irritation study.
Oleic Acid-induced Skin Penetration Effects of a Lamellar Delivery System
Nava Dayan, Ph. D. and P. Batheja and B. Michniak, Ph. D. January 2007
The article reports a novel approach to deliver compounds to skin sub-tissues. Physical characterization and in vitro skin penetration of a delivery system composed of lecithins oleic acid, oil and water are preented. Generation of soft vesicles at lower percentage of oleic acid is shown to aid deeper penetration, while that at high concentration forming lamellar sheets lead to formation of reservoir in SC
Skin Tryptophan and Cross-linked Collagen Levels are Significantly Reduced by Hydroxycinnamic Acid
Nava Dayan, Ph. D. January 2007
Measurement of Tryptophan and pepsin digestible cross linked collagen after UV exposure of human skin is a well known model to simulate and evaluate changes induced by photo-aging. this article documents a clinical study using this model to demonstrate the anti-aging effects of Hydroxycinnamic acid in comparison to well known antioxidants Magnesium ascorbyl phosphate and hydroquinone.
Natural Aging, Suicide or Terminal Illness - The Three Possible Paths for Cell Death
Nava Dayan, Ph. D. November 2006
Every element that has life in it is destined to grow, undergo changes, age and ultimately die. This briefing here elucidates various pathways to programmed cell death. It describes the key players and machinery at cellular level that drive the natural progression of aging and eventually apoptosis or death and implications to divergence from this natural process.
Antimicrobial Compounds (AMC's) as Inhibitors of Bacterial Growth Causing Sweat Malodor
Nava Dayan, Ph. D. and T. Miller May 2006
Here the authors depict anti-microbial activities of natural compounds isolated from human skin surface against sweat malodor causing bacteria. It implicates an approach for use of such natural as safer alternatives to use of chemicals that cause concerns with skin absorption.
StratumCorneum: The Role of Lipids and Ceramides
Nava Dayan, Ph. D. January 2006
This article highlights the role of intercellular lipids and ceramides in stratum corneum structure and function. various models documented in literature to describe its structure are discussed. In essence our understanding of these components is fundamental to innovation of therapies to improve skin barrier and fight various skin conditions.
Photographic Study of LipolightŪ OAP/PVA for the Reduction of the Appearance of Skin Imperfections
Jed A. Riemer, Ph. D. and Nava Dayan, Ph. D. January 2005
LipoLightŪ OAP/PVA consists of 5 micron-sized fluorescent particle that emit and diffuse visible light to reduce the appearance of skin imperfections such as wrinkles and pores. A quantitative clinical study was performed to compare LipoLightŪ OAP/PVA optical effect to commercially available soft-focus powders. The appearance of wrinkles, pores, and evenness of the skin was significantly improved after application of LipoLightŪ OAP/PVA and it was significantly superior to alumina or boron nitride.
Pathways for Skin Penetration
Nava Dayan, Ph. D. January 2005
Delivery of topically applied compounds to the desired levels and targets areas in skin is cirtical to their effectiveness. This article provides a comprehensive overview of various approaches to penetration of skin care actives. It also reveals certain agents and technologies to enhance penetration.
Cosmetic Applications of Cholesteric Liquid Crystals
Jed A. Riemer and Lydia Ortega January 2004
Cholesteric liquid crystals form a unique phase of matter with properties intermediate to solids and liquids. They can be used in cosmetic applications to impart striking visual effects to the products.
